High Sensitivity 0.001 Differential Scanning Calorimeter DSC with Cooling System

Selection Guide for High Sensitivity (0.1μW) Differential Scanning Calorimeters (DSC) with Cooling System

I. Equipment Core Requirements

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Sensitivity: 0.1μW (industry high-end level, can detect weak thermal effects such as glass transition, drug polycrystalline).

Cooling system: realize rapid cooling (e.g. -180℃~725℃), support low-temperature testing (e.g. protein denaturation, low-temperature phase transition).

Application scenarios: Frontier research in material science, biopharmaceuticals, analysis of thermal properties of nanomaterials.

Third, the cooling system comparison

Cooling method

Temperature range

Advantage

Applicable scenes

Mechanical cooling

-90°C to room temperature

Easy operation, low maintenance cost

Routine low-temperature testing (polymer Tg, melt analysis)

Liquid nitrogen refrigeration

-180℃~room temperature

Extremely low temperature capability, fast cooling speed

Ultra-low temperature research (protein denaturation, superconducting materials)

Hybrid refrigeration

-150℃~room temperature

Balance cost and performance, high flexibility

Multi-scenario cryogenic needs (research labs)

IV. Typical applications of high sensitivity DSCs

1. Biopharmaceuticals

Protein denaturation analysis: detect the thermal stability of antibodies during warming (sensitivity 0.1 μW recognizes small conformational changes).

Drug polymorphism: differentiate the weak heat absorption peaks of α-type (melting point 75°C) and β-type (melting point 85°C) of ibuprofen.

2. Nanomaterials

Heat capacity determination: precise measurement of the variation of the specific heat capacity of nanoparticles (e.g. quantum dots) with size.

Phase transition kinetics: analysis of the thermal effects of low-temperature adsorption-desorption of metal-organic frameworks (MOFs).

3. Polymer Science

Weak glass transition: Tg detection of ultrathin polymer films (<100 nm).

Cross-linking reactions: weak exothermic peak integration (calculation of reaction enthalpy) of UV-curable resins.