Apigenin

Name: Apigenin  

Synonyms:  4′,5,7-Trihydroxyflavone

CAS Number:  520-36-5 

Empirical Formula (Hill Notation):  C15 H10 O5 

Molecular Weight:  270.24

Beilstein Registry Number:  262620

MDL number:  MFCD00006831 

PubChem Substance ID:  24846790 

EC Number:  208-292-3

Description

Biochem/physiol Actions: A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2 /M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibitory effects on tumor promotion may also be due to inhibition of kinase activity and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I catalyzed DNA religation and enhance gap junctional intercellular communication.

Other Notes: Inhibitor of human estrogen synthetase1 

Properties

product line       BioChemika 

assay            ≥95.0% (HPLC)

total impurities     ~2% water

mp               >300 °C(lit.)

Safety

F                  10 

Hazard Codes        Xi 

Risk Statements       36/37/38 

Safety Statements     26-36 

WGK Germany       3

RTECS              LK9276000